Naringin effectively reduced the size of fatty streak lesions in the thoracic aorta, inhibited subintimal foam cell infiltration, and suppressed hypercholesterolemia-induced ICAM1 expression on endothelial cells. Furthermore, it demonstrated potent protection against hypercholesterolemia-induced fatty liver and elevations in the levels of liver enzymes. Here, ICAM1 is linked to familial hypercholesterolemia.