CD8A and hepatocellular carcinoma: They can additionally recruit Tregs via production of chemokines and further promote immune evasion via the production of immunosuppressive cytokines such as IL-10, expression of the inhibitory checkpoint ligand PD-L1, and downregulation of MHC II/costimulatory molecules required for successful CD8+ T-cell activation.[9], [10], [22] The presence of TAMs correlates with a worse prognosis in HCC, especially if skewed toward an M2 phenotype.[14], [21], [23]