A compound heterozygous mutation in the ASXL3 (ASXL Transcriptional Regulator 3) gene identified from CHD samples was discovered to promote cell apoptosis or suppress cell proliferation in human cardiomyocytes by inhibiting the Ras/extracellular signal‐regulated kinase signaling pathway.71 The gene discussed is ASXL3; the disease is coronary artery disorder.