Predicted damaging variants in the LRP2 (LDL receptor‐related protein) gene were found to be more prevalent in a cohort of individuals with hypoplastic left heart syndrome (HLHS) or TOF and associated with impaired cardiomyocyte proliferation, underscoring the need for further investigation to elucidate their specific role in the pathogenesis of CHD.67, 68. This evidence concerns the gene LRP2 and hypoplastic left heart syndrome.