The skeletal measurements in Dyrk1a haploinsufficient mice were similar to those found in trisomic or DS model mice, potentially due to alterations in osteoclastogenesis caused by Dyrk1a gene dosage imbalance, and these skeletal phenotypes were normalized in trisomic animals with a normalized copy number of Dyrk1a (Blazek et al., 2015). The gene discussed is DYRK1A; the disease is Dravet syndrome.