From our studies of DS mouse models (Dyrk1a overexpression) and Dyrk1a haploinsufficiency mouse models (Dyrk1a underexpression), DYRK1A dosage imbalance may lead to skeletal alterations that need to be better characterized in individuals with DYRK1A haploinsufficiency syndrome. Here, DYRK1A is linked to Dravet syndrome.