DYRK1A syndrome, also known as DYRK1A haploinsufficiency syndrome and Intellectual developmental disorder, autosomal dominant 7 (MRD7) (OMIM:614104) is generally caused by the presence of a pathogenic variant of DYRK1A, that reduces the functional copy number of DYRK1A from two to one, and likely decreases DYRK1A protein levels (Arranz et al., 2019). The gene discussed is DYRK1A; the disease is DYRK1A-related intellectual disability syndrome.