Furthermore, PcG-mediated miRNA silencing and NF-κB activation were reported among the pathogenic events mediating adult T cell leukemias caused by human T cell leukemia virus type 1 (HTLV-1) (Yamagishi et al., 2012), providing evidence for a direct epigenetic control of inflammatory responses involved in leukemia pathogenesis. This evidence concerns the gene NFKB1 and leukemia.