Other studies have indicated that Notch signaling may mediate hypermethylation of the key erythroid factor globin transcription factor 1 (GATA1) gene which contributes to the ineffective erythropoiesis observed in late MDS (Hopfer et al., 2012); and epigenetic enhancement of Notch activation favored T cell lymphomagenesis in transgenic mice (Wang H. C. et al., 2012). The gene discussed is GATA1; the disease is myelodysplastic syndrome.