BMI1 and cancer: In addition, the miR-137 and miR-214, among others, modulate cancer cell differentiation through the control of EZH2 protein levels, and the downregulation of miR-200 c, miR-203, and miR-183 ensures the expression of BMI1 in mouse embryonic stem cells, and in various cancer cell lines (Anderson and Guttilla Reed, 2020), contributing to the maintenance of the stemness of these cells.