Genomic screening for genes silenced by DNA methylation revealed that Ras-related protein RASD1 suppression correlates with dexamethasone resistance in MM (Rosenberg, 2022), aberrant methylation tends to affect more frequently genes involved in the MAPK signaling pathway in MDS and AML (Aldoss et al., 2019) as well, and Ras-association tumor suppressor genes RASSF6 and RASSF10 are frequently epigenetically inactivated in childhood leukemias (Liu et al., 2020). This evidence concerns the gene RASD1 and acute myeloid leukemia.