A study addressing the role of the gene associated with increased risk for AML Gfi1 (growth factor independence 1) in mouse have revealed that K-Ras driven myeloproliferative disorders induce mutations in Gfi1 gene, whose associated loss of functions induces histone modifications resulting in the expression of Hoxa9 gene and other genes involved in the development of leukemia (Khandanpour et al., 2012). This evidence concerns the gene GFI1 and leukemia.