Equally, downregulation of dual specificity phosphatase 22 (DUSP22) expression, elevation of phosphorylation of the H2AX histone (p-H2AX), reduced level of Histone H3 at Ser10 (H3S10), and the phosphorylation of T-LAK cell-originated protein kinase (TOPK) at Y74 and Y272 are observed in colorectal cancer (Qin et al., 2020). The gene discussed is DUSP22; the disease is colorectal cancer.