Phosphorylation occurs on hydroxylated aminoacids tyrosine, serine, and threonine.H2Bser32p is extensively phosphorylated by RSK2 kinase in skin cancer cells (Lau et al., 2011).In addition, androgen stimulation protein kinase C-beta (PKCβ) and protein kinase C related kinase 1 (PRK1) phosphorylate H3tre6 and 11 respectively in prostate cancer cells (Metzger et al., 2010). Here, PKN1 is linked to Familial prostate cancer.