AKT1 and acute myeloid leukemia: A study addressing the role of the pro-inflammatory transcription factor CREB in AML cell abnormalities (Takao et al., 2021) revealed an overexpression of its target genes, such as NF-κB, JAK1, STAT3, the cell cycle regulators cyclin A1, B1, D, and the apoptosis regulator Bcl-2; survival signaling pathways, including Akt, mTOR, and ERK, were also concomitantly activated.