Genes encoding for Wnt antagonists are silenced by hypermethylation in several HMs, including genes such as secreted Frizzled-related proteins (sFRP), Dickkopf 3 homolog (DKK3), adenomatous polyposis coli complex (APC), human homolog of Dapper 1 (HDPR1), and Wnt inhibitory factor 1 (WIF1) in MM (Guo et al., 2017), MDS (Reins et al., 2010), AML (Gruszka et al., 2019), and CLL (Urbano et al., 2019). The gene discussed is DKK3; the disease is B-cell chronic lymphocytic leukemia.