Furthermore, the AML fusion protein NUP98-NSD1is an active H3K36 KTM (Liu et al., 2020), and the multiple myeloma (MM) SET domain (NSD2 or MMSET) is a KTM involved in the t (4; 14)(p16; q32) translocation, a recurrent chromosomal translocation present in MM andassociated with poor prognosis. Here, NSD2 is linked to acute myeloid leukemia.