OGG1 and acute myeloid leukemia: Recent reports have indicated that the pivotal component of the DNA base excision repair pathway 8-oxoguanine glycosylase (OGG1), which removes 8-oxoguanine nucleotides from DNA (thereby suppressing mutagenesis and rescuing cells from apoptosis) was significantly downregulated by the RUNX1-ETO leukemia fusion protein in both normal hematopoietic progenitor cells and in cells from AML patients (Liddiard et al., 2010).