Following the restoration of secreted Klotho (sKL) expression, studies found a decrease in F4/80 and CD68 co-tagged M1, a suppression of monocyte chemoattractant protein-1 (MCP-1) and intercellular adhesion molecule 1 (ICAM-1) expression on the aortic valves of senescence-accelerated mice prone strain 1 (SAMP1) mice, and a reduction in aortic valve fibrosis along with aging-associated vascular inflammation (44). Here, CCL2 is linked to inflammatory response.