Patients with T-cell lymphoma have much lower levels of Klotho in their lymph nodes than in normal lymph nodes; the overexpression of Klotho can control the growth of T-cell lymphomas and decrease insulin-like growth factor-1 receptor (IGF-1R) signaling, which has anticancer properties (53). The gene discussed is IGF1R; the disease is T-cell non-Hodgkin lymphoma.