KLB and hepatocellular carcinoma: Pediatric non-alcoholic fatty liver disease (NAFLD) patients experience hepatic injury and an increased risk of ballooning and lobular inflammation as a result of the organism downregulating β-Klotho through the expression of the rs17618244 G>A β-Klotho variant in human liver carcinoma (HepG2) and human HCC cell line (Huh7 cells).