KL and renal fibrosis: In addition to animals, estrogens in plants also induce Klotho transcriptional activation, e.g., genistein )a phytoestrogenic isoflavone enriched in dietary soy products(protects Klotho levels and mitigates renal fibrosis in UUO mice by reversing HDAC3 deacetylation of the Klotho promoter while inhibiting aberrant expression of DNMT1/3a (149).