EGFR and non-small cell lung carcinoma: In NSCLC cells, GPCR transactivation of EGFR plays an important role in proliferation, migration, and drug resistance (86)—for example, protease-activated receptors (PARs), a subfamily of G protein-coupled receptors (GPCR), play important roles in hemostasis, thrombosis, embryonic development, wound healing, and inflammation (87).