In individuals with the multibacillary form of leprosy (MB), high levels of antibodies directed to PGL-1 and LID-1 were detected, indicating its efficiency in identifying MB occurrences. Similar to IFN-γ quantification, CXCL10/IP-10 detection provided data enabling the distinction between PB and EC individuals, but it was not able to differentiate PB and HHC. This evidence concerns the gene IFNG and leprosy.