(B.2.1) Endothelial cells stimulated by IL-37 expression through the secretion of inflammatory mediators, including IL-1β, TNF-α, and IFN-γ, which positively induce adhesion molecules like E-selectin, ICAM-1, VCAM- 1, and VLA-4 that allow immune cells to go to the infection site. The gene discussed is IL37; the disease is infection.