CD44 and neoplasm: CD44, a kind of cell-surface glycoprotein, plays a role in angiogenesis, cytoskeleton rearrangement, tumor proliferation, cell adhesion, and migration (23).In recent years, studies have shown that a CD44-targeted hyaluronic acid-curcumin prodrug protects renal tubular epithelial cell survival from oxidative stress damage (24).Interestingly, CD44 contributed to the recruitment of monocyte/macrophages to the kidney following IRI (25).