ICD is associated with the emission of several damage-associated molecular patterns (DAMPs), including extracellular ATP and high motility group protein1 (HMGB-1); translocation of the endoplasmic reticulum chaperone calreticulin (CALR) to the plasma membrane; and active secretion of numerous immunostimulatory or chemotactic cytokines including type I interferons (IFN-I) and C-X-C motif chemokine ligand 10 (CXCL10) to the tumor microenvironment (9–11). The gene discussed is CALR; the disease is neoplasm.