These cells are then differentiated into immature DCs in the presence of granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4) while being pulsed with TAAs or tumor cell lysates, together with stimulation in a maturation cocktail comprising TNF-α, IL-1β, IL-6, and PGE2 (47). The gene discussed is CSF2; the disease is neoplasm.