Having in mind that tolDC, type 3 innate lymphoid cells (ILC3) and Treg exhibit high expression of AHR (9), our aim was to explore the effects of AGT-5, a member of the new class of fluorescent AHR ligands (FluoAHRL) on multiple low dose streptozotocin (STZ)-induced T1D development in mice (18, 19). This evidence concerns the gene AHR and type 1 diabetes mellitus.