Previous research has suggested that obese individuals without T2DM experience enhanced FNDC5 synthesis and subsequent irisin release, potentially contributing to the regulation of glucose retention in muscles and preventing hyperglycemia and obesity (Aladag, Mogulkoc & Baltaci, 2023; Perakakis et al., 2017). The gene discussed is FNDC5; the disease is obesity due to melanocortin 4 receptor deficiency.