A previous review study reported that several cellular HSPs interact with HIV-1 proteins and virions, and thus may be involved in the progression of HIV-1 infection, such as HSP40 and HIV-1 Nef protein to enhance viral translocation into the nucleus, HSP70 and HIV-1 virions as well as HIV-1 gag protein, and may be involved in the viral uncoating process, HSP90 blocks p-TEFb to suppress reactivation from latency. Here, HSPA1A is linked to HIV-1 infection.