Pregnancy-associated plasma protein-A (PAPP-A) was originally identified as an antigen abundantly present in the circulation at late pregnancy [1], being secreted by the placental syncytiotrophoblasts [2], and today PAPP-A serves as a routine biomarker for fetal chromosomal abnormalities (e.g., Trisomy 21) [[3], [4], [5]]. Here, PAPPA is linked to trisomy 21.