ADRA2C and cancer: According to the analysis of genetic alterations performed in the present study, different ADRA2C mutation types were included and alterations in DNA methylation level appeared in several cancer types, demonstrating that ADRA2C may participate in the tumorigenesis, especially in BLCA, BRCA, COAD, HNSC, KIRP, LUAD, LUSC, PAAD, and PRAD.