Similarly, combined analysis of the 165 ROS-associated genes with the 3352 downregulated DEGs revealed 22 candidate ROS-associated downregulated DEGs in COAD, including LRPK2, TLR6, CYBB, ATP7A, HIF1A, CD36, CYP1B1, P2RX7, NOX4, TLR2, SH3PXD2A, BCL2, AGTR1, FBLN5, PDK4, THBS1, ITGAM, PDGFRB, EDN1, LEP, SFTPD, and MAPT. The gene discussed is PDK4; the disease is colon adenocarcinoma.