SLC25A39 and colorectal carcinoma: Consistent with these findings, our current investigation revealed that the knockdown of SLC25A39 resulted in heightened ROS accumulation, suggesting that the reduction in mitochondrial GSH import mediated by SLC25A39 knockdown impairs the cell's ability to effectively eliminate or neutralize ROS generated from mitochondria, thereby leading to increased ROS levels in colorectal cancer (CRC).