Similarly, combined analysis of the 165 ROS-associated genes with the 3352 downregulated DEGs revealed 22 candidate ROS-associated downregulated DEGs in COAD, including LRPK2, TLR6, CYBB, ATP7A, HIF1A, CD36, CYP1B1, P2RX7, NOX4, TLR2, SH3PXD2A, BCL2, AGTR1, FBLN5, PDK4, THBS1, ITGAM, PDGFRB, EDN1, LEP, SFTPD, and MAPT. Here, THBS1 is linked to colon adenocarcinoma.