Conversely, pathways enriched with downregulated DEGs encompassed PI3K-Akt signaling, calcium signaling, cytokine-cytokine receptor interaction, cell adhesion molecules, focal adhesion, phagosome, ECM-receptor interaction, cholinergic synapse, hematopoietic cell lineage, and malaria (Fig. 4E and Fig. S2D). Here, AKT1 is linked to malaria.