The equation for the risk model (named as CAF.SENESCENCE.SIG) was as follows: risk score = + 0.13857990 * SLC2A6 - 0.24928075 * GEM - 0.07930229 * CXCL14 - 0.34867227 * STX11 + 0.54549264 * EFHD2 + 0.01091528 * PTX3 - 0.26066936 * HCK. Subsequently, ESCC patients in GSE53624 and TCGA datasets were divided into two groups (Figure 6A-B). The gene discussed is EFHD2; the disease is esophageal squamous cell carcinoma.