Among them, LY6H has been found in bladder urothelial carcinoma (BLCA), cholangiocarcinoma (CHOL), glioblastoma multiforma (GBM), head and neck squamous cell carcinoma (HNSC), kidney chromophilous cell carcinoma (KICH), kidney clear cell carcinoma (KIRC), kidney papillary cell carcinoma21, primary liver cancer (LIHC), lung squamous cell carcinoma (LSSC), pheochromocytoma and paraganglioma (PCPG) are expressed higher in tumors than in normal tissues. The gene discussed is LY6H; the disease is pheochromocytoma-paraganglioma.