Leveraging patient information from TCGA, GTEx, UALCAN, cBioportal, UCSC, CTD, cancerSEA databases, we conducted an extensive analysis on the differential expression of LY6H across 33 human cancers to explore its associations with diagnosis, prognosis, immune infiltration, methylation patterns, genetic alterations, tumor stemness characteristics and chemical substances. This evidence concerns the gene LY6H and neoplasm.