In STZ-induced DN rats, AS-IV could also alleviate ER stress-induced podocyte apoptosis by suppressing the PERK-ATF4-CHOP pathway [88]; inhibiting the expression of ORP150 and GRP78; and downregulating the phosphorylation of PERK, eIF2α, and JNK [89]. The gene discussed is EIF2AK3; the disease is liver dysplastic nodule.