NFKB1 and liver dysplastic nodule: APS and calycosin could also ameliorate inflammation in DN kidneys by suppressing the NF-κB-dependent signaling pathway, confirmed by the downregulation of Toll-like receptor 4 (TLR4) and the phosphorylation of IκBα and NF-κB p65 and the expression of TNF-α, IL-1β, and MCP-1 in diabetic rats/mice, AGEs-treated mouse TECs, and HG-treated mouse podocytes [103–105].