Thus, the stimulation with common γ-chain cytokines up-regulates PD-1 and TIM-3 during the proliferation of initially PD-1/TIM-3-non-expressing T lymphocytes, but does not lead to the expansion of PD-1- and TIM-3-expressing cells of MM patients in vitro. This evidence concerns the gene HAVCR2 and Miyoshi myopathy.