Althoughchoroidal melanoma cells exhibit a low level of autophagy (15), GABARAPL1, through itsconnection with phospholipids, inhibits lysosomal activity, binds to intracellularmembranes, and accumulates in vesicles to regulate autophagy levels in tumor cells.Furthermore, research has shown that GABARAPL1 caninfluence tumor angiogenesis by regulating the secretion of exosomes, thus impactingtumor growth, necrosis, and therapeutic efficacy. This evidence concerns the gene GABARAPL1 and neoplasm.