CETP and metabolic syndrome: Similarly, a prospective, randomised, single-blind controlled dietary intervention trial (Coronary Diet Intervention With Olive Oil and Cardiovascular Prevention) involving 424 Spanish individuals with metabolic syndrome(113) found significant interactions between the CETP SNP rs3764261 and Mediterranean diet on the concentration of HDL-cholesterol (Pinteraction = 0·006) and TAG (Pinteraction = 0·04).