FFAR2 and hepatocellular carcinoma: Acetate binds to the G protein‐coupled receptor 43 of liver cells, activates GPR43, and inhibits the IL‐6/JAK1/STAT3 signaling pathway, thereby suppressing NAFLD‐HCC formation.[26] Our study, which has been causally validated at the genomic level and in a mouse model of DSS‐induced colitis, confirms that B. pseudolongum promotes the production of secondary bile acids in the intestine, in particular the levels of HDCA and 12‐KCAC, to alleviate colitis.