The Gucy1A gene encodes the alpha 1 subunit of soluble guanylate cyclase (sGC), which forms a heterodimeric enzyme with the encoded beta 1 subunit and serves as the primary receptor for nitric oxide (NO).[27] The binding of NO to the haem iron of sGC induces the production of cGMP and subsequent activation of the cGMP‐ PKG pathway.[12] Previous studies on the function of the Gucy1A gene have mainly focused on cardiovascular diseases,[28] and its role in the regulation of intestinal inflammation remains largely unknown. The gene discussed is SGCB; the disease is cardiovascular disorder.