GUCY2C and inflammatory bowel disease: GC‐C, encoded by Gucy2C, is primarily expressed in intestinal epithelial cells,[11] where it responds to enterotoxins and endogenous ligands such as guanylin and uroguanylin.[12] It plays a critical role in regulating intestinal fluid and electrolyte secretion, maintaining water and salt balance, and contributing to epithelial cell proliferation and differentiation.[13] However, it remains unclear whether dysregulation of the GC1 signaling pathway is associated with the onset of IBD.