In contrast, extensive research has already elucidated the involvement of the Gucy2C gene in the regulation of intestinal inflammation and tumor development, revealing the dysregulation of the Gucy2C‐cGMP signaling axis in the pathogenesis of intestinal transport disorders, inflammatory bowel diseases, and colorectal cancer.[29, 30, 31] According to our data, the Gucy1A protein is involved in regulating the expression of Gucy2C to modulate the concentrations of Ca2+ and cGMP in colon cells. The gene discussed is GUCY2C; the disease is neoplasm.