Significantly, the association between microbial bile acid metabolism and IBD has been repeatedly substantiated.[5, 6, 7] Microorganisms harboring bile salt hydrolase (BSH) enzymes can convert primary bile acids to secondary bile acids within the intestines, synergistically ameliorating IBD progression.[8, 9] Our previous studies have further demonstrated that pivotal bile acid metabolites such as α‐muricholic acid (α‐MCA), hyodeoxycholic acid (HDCA), and isolithocholic acid (isoLCA) indirectly inhibit the differentiation of Th17 cells and modulate the IL‐17 signaling pathway. This evidence concerns the gene IL17A and inflammatory bowel disease.