In our study, RSL3@LIPO@GEL markedly increased tumor infiltration of M1 macrophages, CD4+ T cells, and CD8+ T cells and significantly reduced the number of M2 macrophages and Tregs, indicating that the anticancer therapeutic effect of RSL3@LIPO@GEL was not only derived from ferroptosis of tumor cells but also from orchestration of the TME. Here, CD8A is linked to neoplasm.