Ferroptosis is a recently discovered form of cell death that occurs via iron‐dependent cell membrane lipid peroxidation.[10] Recent studies have shown that breast cancer is particularly susceptible to ferroptosis.[11] Ferroptosis‐inducing drugs have been found to effectively suppress malignant tumors, including breast cancer, and to enhance the anti‐tumor immune response.[12] RSL3 is a small molecule inducer of ferroptosis that inhibits the synthesis of glutathione peroxidase 4 (GPX4), which is the major phospholipid hydroperoxide (PLOOH)‐neutralizing enzyme. The gene discussed is GPX4; the disease is breast cancer.