The authors additionally found that UDP‐treated B16 melanoma cells‐engrafted C57BL6 mice showed a high expression of anti‐tumour immune response markers; tumour‐infiltrating T‐lymphocytes (TILs) CD3+ CD8+, and CD3+CD4+, and the major histocompatibility class II high tumour‐associated macrophages (MHC II)HI TAM, which are associated with tumour suppression in early tumour development [80]. This evidence concerns the gene CD4 and melanoma.