We report novel data on the combined effects of HIFT and spinach-thylakoid extract on specific adipokines in males with obesity in an intervention study involving measurements of cardiorespiratory parameters, daily nutrition intake, lipid profile, and the plasma levels of a novel anti-inflammatory adipokine, CTRP12 and its key regulatory factors KLF15 and furin. Here, KLF15 is linked to obesity due to melanocortin 4 receptor deficiency.