The adipose-derived insulin-sensitizing factor adipolin-related C1q/TNF-related Protein-12 (CTRP12) is such a newly described adipokine with anti-inflammatory and insulin-sensitive effects that can counteract complications involved with obesity, inflammation, as well as diabetes [7–9]. The gene discussed is C1QTNF12; the disease is obesity due to melanocortin 4 receptor deficiency.