Expression of CTRP12 in adipocytes is regulated by various factors, among which the Kruppel-like factor (KLF-15) and furin have gained much attention and suggest that studies to explore the mechanism and treatment of obesity should consider in-depth interventions with beneficial adipokines along with their regulatory factors [12]. Here, C1QTNF12 is linked to obesity due to melanocortin 4 receptor deficiency.