SOCS3 and liver cancer: SOCS1 alterations through SOCS7 and CISH alterations were detected in liver cancer tissues at the following frequencies: SOCS1, 1.1%; SOCS2, 0.8%; SOCS3, 6%; SOCS4, 0.3%; SOCS5, 1.3%; SOCS6, 1.3%; SOCS7, 2.4%; and CISH, 2.7% (Figure 2A).