The results indicated that the promoter methylation levels of SOCS1 (p– = 7.379E‐07), SOCS3 (p = 4.534E‐10), SOCS5 (p = 1E‐12), SOCS6 (p = 5.534E‐11), and CISH (2.273E‐05) were lower in cancer tissues than in normal tissues. This evidence concerns the gene SOCS5 and cancer.