The ability of eight SOCS family members to predict the prognosis of HCC patients was also assessed, and the results indicated that the levels of SOCS2 (p < 0.0001), SOCS4 (p = 0.0064), SOCS5 (p = 0.034), SOCS6 (p = 0.037), and CISH (p = 0.034) were significantly related to OS in HCC patients (p = 0.034) (Figure 4). This evidence concerns the gene SOCS4 and hepatocellular carcinoma.