As shown in Figure 1, compared with those in normal liver tissues, the mRNA expression levels of SOCS2 (p = 1.2E‐15), SOCS3 (p = 1.3E‐09), SOCS6 (p = 0.00014) and CISH (0.0011) decreased in HCC tissues, while the expression levels of SOCS4 (p = 1.1e‐06), SOCS5 (p = 2.4E‐12), and SOCS7 (p = 2.22E‐16) increased significantly. The gene discussed is CISH; the disease is hepatocellular carcinoma.