TRPS1 and colonic neoplasm: For example, a recent study demonstrated a replication-boosting role of TRPS1 in H3K9me3-marked heterochromatic origin activation and cancer genome evolution.8 Another study suggested that TRPS1 might act to enhance FOXA1 expression by engaging with its promoter, further broadening its previously understood role as a transcriptional repressor.9 Several other studies have reported that TRPS1 could act as a breast cancer driver, but the role of TRPS1 in colon cancer remains unclear.