Dysregulation of EMT signaling is frequently observed in the progression of cancer aggressiveness.35 ZEB1, a key transcription factor of EMT, is often upregulated during carcinogenesis, thereby activating EMT pathways.36 TRPS1, an atypical GATA transcription factor, has been identified as a key regulator of the mesenchymal-to-epithelial transition, affecting the formation and specialization of various tissues.37–39 Despite its known roles, the mechanism by which the TRPS1 R544Q mutation influences EMT signaling to enhance the metastatic phenotype in colorectal cancer remains unknown. The gene discussed is TRPS1; the disease is cancer.