It provokes the secretion of pro-inflammatory cytokines IL-6 and IL-8 in human periodontal ligament cells (hPDLCs) via binding to the obesity-related leptin and leptin receptor b (OBRb), thereby triggering subsequent intracellular signaling cascades [73]. This evidence concerns the gene CXCL8 and obesity due to melanocortin 4 receptor deficiency.