NHL-HLH组CD4+ T和CD8+ T细胞CD28表达比例中位数分别为96.7%和68.9%,均显著高于对照组的90.3%和49.0%(P<0.001;P=0.005)。此外,NHL-HLH组中CD8+ T细胞CD38和HLA-DR表面激活标志物表达中位数分别为57.4%和49.7%,也显著高于对照组的21.5%和33.5%(P<0.001;P=0.028)。. This evidence concerns the gene CD28 and non-Hodgkin lymphoma.