UBA1 and hematologic disorder: VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) syndrome is a recently described autoinflammatory and hematologic disorder caused by somatic mutations in the UBA1 gene (located in the X chromosome), which encodes the ubiquitin-activating enzyme 1 required for ubiquitination process pathways.