TP53 and gastric cancer: Meanwhile, the Asian Cancer Research Group has categorized GC into four subtypes based on gene expression data, each associated with a distinct clinical outcome: microsatellite unstable, microsatellite stable and epithelial-to-mesenchymal transition (MSS/EMT), MSS/TP53+ (TP53 active), and MSS/TP53- (TP53 inactive).