INS and Floating-Harbor syndrome: One of the key contributors to the progression of FLHS is insulin resistance (Zhuang et al., 2019), while adiponectin is an insulin-sensitizing and anti-inflammatory agent (Peake et al., 2005; Shetty et al., 2009) which plays a vital role in maintaining glucose and lipid homeostasis (Yamauchi et al., 2002).