The expression of nine genes (TSC22D1, SNCA, SH3YL1, KCNA3, RNF135, TM6SF1, PRDM2, BVES and AMN) was reduced (Fig. 4B), while that of eight genes (VASH2, MAFA, LRRC10B, PIK3R3, TRIL, CELSR3, IDUA and SEPT9) was increased (Fig. 4C) in HCC compared to control livers. The gene discussed is PRDM2; the disease is hepatocellular carcinoma.