We also found a direct relation between the concentration of IL-1β and the expression of CCL2. This sustained upregulation in the expression of CCL2 both under treatment with ACM and IL-1β, highlights an important role of the aforementioned CCL2-CCR2 axis in obesity-associated CC carcinogenesis. The gene discussed is IL1B; the disease is obesity due to melanocortin 4 receptor deficiency.