Interestingly, Mellios et al. [42] found an upregulation of hsa-miR-302a-3p in cultured neurons and neural progenitors with, just as our hiPSC cell line, a MECP2 mutation in the transcription repression domain (TRB), further emphasizing the importance of this miRNA cluster in RTT pathogenesis. The gene discussed is MECP2; the disease is Rett syndrome.