SOD1 and amyotrophic lateral sclerosis: When comparing individuals with ALS to their spouses within one year of diagnosis, Akkermansia levels were elevated only in ALS patients.92 In mice expressing an ALS-associated human mutated superoxide dismutase 1 (SOD1.G93A), there is a decrease in the Akkermansia relative abundance as the disease progresses compared to wild-type littermates.