METABRIC integrates the subtyping of BC-based copy number alterations (CNAs) and gene expression in primary tumors and has revealed ten integrative clusters (IntClust 1–10).64 The Cancer Genome Atlas (TCGA) identified four major breast cancer subtypes via multiplatform clustering.65 Shao et al.66 assembled a large-scale multi-omics cohort comprising 579 patients with HR+/HER2- BC and classified them as canonical luminal, immunogenic, proliferative, and receptor tyrosine kinase (RTK)-driven molecular subtypes. This evidence concerns the gene ERBB2 and breast cancer.