Beyond psychiatric implications, Syne1 has been linked to a range of genetic disorders, such as autosomal recessive cerebellar ataxia type 1 (ARCA1), Emery-Dreifuss muscular dystrophy, and myogenic arthrogryposis, indicating its crucial role in neurological disorders [104–107]. Here, SYNE1 is linked to autosomal recessive ataxia, Beauce type.