AKT1 and familial pancreatic carcinoma: Similarly, it was suggested that exosomal lncRNA from laryngeal carcinoma tissues were capable to induce type 2-like macrophage polarization via the PI3K/p-AKT/AKT signaling pathway [42] and also exosomes from pancreatic cancer cell lines increased the expression patterns of markers indicative for a an immunosuppressive M2-like macrophage polarization [43].