Activation of STING-TBK1-Zyxin signaling was evident in B16-F10 melanoma (Fig. EV6A), and phospho-Zyxin induced upon cGAMP administration were mainly in F4/80+ macrophages and, to a lesser extent, in CD4+ T cells (Fig. EV6B,C). Here, TBK1 is linked to melanoma.