Rapid activation of cGAS-STING signaling could robustly inhibit tumor growth; however, tumor-derived cGAMP and chronic inflammation caused by DNA-damage response (DDR), chromosomal instability (CIN), mtDNA release, and dying cells may promote tumor progression (Bakhoum et al, 2018; Hou et al, 2018). Here, CGAS is linked to neoplasm.