THBS1 and Familial prostate cancer: As we also observed a significant increase of THBS1 in clinical prostate cancer tissues, with higher GS (Fig. 6e, f) and increased abundance of THBS1 in localized tumors, and bone metastases (Fig. 6g), our data are in line with the previous observation that THBS1 can promote tumor aggressiveness in advanced prostate cancer [17].