To combine various biomarkers of malnutrition and inflammation, previous studies have developed several composite systemic inflammatory indexes, including SIRI, ALI, LMR, NLR, PLR, PNI, and SII, and malnutrition indexes, including NRI and CONUT, are significantly correlated with the prognosis of NSCLC patients receiving EGFR-TKI treatment in this study. This evidence concerns the gene EGFR and malnutrition.