An increase in neutrophils in peripheral blood leads to the upregulation of tumorigenic and angiogenic factors, e.g., vascular endothelial growth factor (VEGF), nuclear factor kappa B (NF-κB), CXC chemokine ligand 8 (CXCL8), granulocyte colony-stimulating factor (G-CSF), and transforming growth factor-β1 (TGF-β1), which induce a tumor-promoting environment [25]. This evidence concerns the gene TGFB1 and neoplasm.