In this study, clinical information from 363 NSCLC patients receiving EGFR-TKI treatment at our clinical center was used for analysis to evaluate nutritional and systemic inflammation-related indexes (including NRI, SIRI, ALI, CONUT, LMR, NLR, PLR, PNI, and SII), as well as their optimal combination for predicting clinical outcomes in patients with NSCLC. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.