Finally, a significant association could be observed between the expression of these genes and the dysregulation of immune cells, along with drug sensitivity.<h4>Conclusions</h4>In summary, our study identified six hub genes, namely SLC14A1, COL4A6, MYOF, FLRT3, KRT15, and LAMB3, which can be utilized to establish a diagnostic model for PCa. Here, KRT15 is linked to posterior cortical atrophy.