First, in accordance with the observed CM size increase (Fig 1B), higher expressed DEGs were associated with cardiac hypertrophy (e.g., Nppa, Gpx3, Sparc; Fig 3C and Table S4) (Farrell et al, 2018; Cibi et al, 2020; Vigil-Garcia et al, 2021). Here, SPARC is linked to cardiac hypertrophy.