The absence of an association with hsCRP, as opposed to the findings of Bienstock et al,9 may be attributed to the smaller sample size and the lower and less variable hsCRP levels in our study, but might also be explained by hsCRP’s non-causal association with ASCVD and its weaker association with clinical events compared with IL-6, suggesting that IL-6 might hold greater clinical relevance as a risk factor for ASCVD compared with the relatively nonspecific hsCRP.25 Here, IL6 is linked to atherosclerosis.