AFP and intrahepatic cholangiocarcinoma: For example, one study developed an intrahepatic cholangiocarcinoma (ICC) scoring system (ie, −2.474−2.554×elevated Alpha-fetoprotein+2.537×elevated CA 19-9+2.451×obscure lesion boundary+3.164×Rim-like hyperenhancement+1.976×wash-out onset within 45s+2.976×marked wash-out within 3 min).19