Through the activation of constitutive Ca2+ entry in MCF7 breast cancer cells, Orai1α incorporates extracellular Ca2+ into the cytosol, which is subsequently transferred to the Golgi by SPCA2, to be finally secreted to the extracellular compartment as insoluble Ca2+ phosphates, resulting in calcification. The gene discussed is ATP2C2; the disease is breast carcinoma.