Smaardijk et al. reported that SPCA2 couples Orai1-mediated constitutive Ca2+ entry with the Golgi/secretory pathway in human embryonic kidney HEK293 and adenocarcinoma HelaT1 cells, so that SPCA2 transfers the internalized cytosolic Ca2+ to the Golgi, which, in turn, is secreted to the extracellular compartment. Here, ATP2C2 is linked to adenocarcinoma.