Along similar lines, preclinical models show that activities of KMT2A and the opposing H3K4 demethylase KDM5A (Lysine-specific demethylase 5A), a histone lysine demethylase mutated in several neurodevelopmental disorders (36, 37), are tightly balanced such that the behavioral and structural effects due to the depletion of either are restored to a degree by depleting their respective counterpart (38). Here, KDM5A is linked to neurodevelopmental disorder.